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《Chinese Journal of Practical Nervous Diseases》 2015-17
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The associated research between gene polymorphism and sporadic Parkinson's disease in the Minnan region of China

Fang Jie;Guo Mingwei;Chen Shuai;Lin Qing;Ma Qilin;The First Clinical Medical College of Fujian Medical University;  
Objective To research the correlation between the SNP of SNCA(rs356221),ITGA8(rs7077361),LRRK2(rs1491942)and sporadic PD in the Minnan region of China.Methods One hundred and sixty eight inpatients and outpatients with complete clinical information of PD and without family history of PD,and one hundred and seventy seven healthy controls were respectively recruited at department of neurology and physical examination center in the first hospital of Xiamen from August 2011 to December 2013.The target gene loci was genotyped by the SNaPshot technique,and the SNP data were statistically analyzed by Chi-square test and Fisher exact probability method.Results(1)The genotype and allele frequencies of rs1491942 in LRRK2showed statistically great difference between SPD group and control group(P=0.008/0.007),and there was statistically great significance between(CC+CG)and GG(P=0.003);According to age stratification and sex stratification,just LOPD and women's group showed statistically great difference compared with control group(P=0.006/0.001).(2)The genotype and allele frequencies of SNSA(rs356221)and ITGA(rs7077361)showed no statistically great difference between SPD group and control group(P=1.000).Conclusion(1)The SNP of LRRK2(rs1491942)may be related to late sporadic PD in women patients,and allele rs1491942-C may be a risk factor for Han Chinese in Minnan region.(2)The SNP of SNCA(rs356221)and ITGA8(rs7077361)may have nothing to do with SPD in the same area.
【Fund】: 福建省自然科學基金重點項目(2012D062)
【CateGory Index】: R742.5
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhao Hui;Dong Liguo;Mu Yingfeng;Chen Yumin;Yang Xinxin;Ding Xinsheng;Neurological Department of Cental Hospital;;A research on polymorphisms of PINK1,LRRK2 in patients with Parkinson's disease[J];中國實用神經疾病雜志;2013-24
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 Fang Jie;Guo Mingwei;Chen Shuai;Lin Qing;Ma Qilin;The First Clinical Medical College of Fujian Medical University;;The associated research between gene polymorphism and sporadic Parkinson's disease in the Minnan region of China[J];中國實用神經疾病雜志;2015-17
2 PANG Guo-Fang;LIANG Qing-Hua;Lü Ze-Ping;Department of Neurology,Jiangbin Hospital;;The polymorphism of PARK2 and LRRK2 gene for Zhuang patients with sporadic Parkinson's disease in Guangxi area[J];中國老年學雜志;2015-11
3 PANG Guofang;LIANG Qinghua;LV Zeping;HU Caiyou;HUANG Dongting;ZHOU Bofeng;HUANG Chunli;YU Tianzhi;TANG Fengchuan;QIN Jiaoqin;YANG Ze;Department of Neurology,Jiangbin Hospital;Beijing hospital;;Association study on the polymorphism of LRRK2 gene for Zhuang Patients with Parkinson's disease[J];中國老年保健醫學;2015-02
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Xuewei1,ZHANG Hainan3,LIAO Bing1,GUO Jifeng1,XIA Kun2,TANG Beisha1(1.Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008;2.State Key Laboratory of Medical Genetics,Changsha 410008;3.Department of Neurology,Second Xiangya Hospital,Central South University,Changsha 410011,China);Mutation analysis of PINK1 gene in patients with early-onset Parkinsonism[J];中南大學學報(醫學版);2011-06
2 Liu Liangfang,Chen Yusen,Liu Zhou,et al.Department of Neurology,Affiliated Hospital,Guangdong Medical College,Zhanjiang 524001,China;Association between tag polymorphism rs17587319 of autophagy-related gene 5(Atg5) and Parkinson's disease[J];中國實用神經疾病雜志;2010-09
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