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《Chinese Journal of Critical Care Medicine》 2019-06
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Effect of Apelin-13 on myocardial remodeling in the rabbits with acute myocardial infarction

Zhang Bo;Zhang Yan-hong;Chen Li-tao;Emergency Internal Medicine Jilin Provincial People's Hospital;  
Objective To explore the effect of Apelin-13 on myocardial remodeling in the rabbits with acute myocardial infarction(AMI).Methods Rabbit AMI models were established by ligation of open chest coronary artery.They were randomly divided into three groups:sham operation group(n=10),AMI control group(n=10),and Apelin-13 group(n=10).AMI rabbits were given medication after operation,and Apelin-13 was injected by 0.1 mg/(kg · d)through ear vein for 7 consecutive days.AMI control group and sham operation group were injected with the same amount of saline.One or two weeks after operation,5 mL of vein blood was collected from the ear margin,and 2 weeks later,the animals were sacrificed.Vascular endothelial growth factor(VEGF)in blood was detected,cardiomyocyte apoptosis index(AI)was calculated,heart weight to body weight ratio was obtained,myocardial collagen content was determined and heart samples were fixed for pathological analysis.Results Compared with AMI control group[VEGF after one week(70.59±9.46)ng/L and VEGF after two weeks(59.72 ±4.17)ng/L,AI(73.97 ±5.03)%,heart weight and body weight ratio(2.7 ±0.11)‰,myocardial collagen content(26.85 ± 1.43)mg/g],VEGF after one week(584.02±5.24)ng/L and VEGF after two weeks(68.65±4.91)ng/L in Apelin-13 group increased significantly(P0.01), AI decreased significantly[(65.73 ±4.42)%,P0.01],heart weight and body weight ratio[(2.60±0.15)‰,P0.05],myocardial collagen content decreased significantly[(24.93±1.37)mg/g,P0·05]· Special staining showed that in AMI control group,the proliferation of collagen components around blood vessels was obvious.Collagen deposition in Apelin-13 group was significantly reduced than that in AMI control group.Conclusion Apelin-13 promotes neovascularization in AMI rabbits,forms collateral circulation as early as possible,effectively inhibits myocardial apoptosis and improves myocardial remodeling.
【Fund】: 吉林省衛生技術創新項目(2016J016)
【CateGory Index】: R542.22
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 TAO Yang;ZHANG Zhi;WANG Yingying;Department of Cardiology, The Third Affiliated Hospital of Liaoning Medical university;Department of Cardiology, The First Affiliated Hospital of Liaoning Medical university;;Effect of apelin-13 on myocardial fibrosis in hypertensive rats and its underlying mechanism[J];解放軍醫學院學報;2015-03
2 LI Hong-qing1,2,ZHANG Zhi3,JIAO Hui3,MA Qing-hua4 1School of Preclinical Medicine,Liaoning Medical College,Jinzhou 121001,Liaoning Province,China;2Department of Endocrinology,Panjin Central Hospital,Panjin 124000,Liaoning Province,China;3Department of Cardiology,Third Affiliated Hospital of Liaoning Medical College,Jinzhou 121001,Liaoning Province,China;4Department of Cardiology,First Affiliated Hospital of Liaoning Medical College,Jinzhou 121001,Liaoning Province,China;Effect of apelin-13 on myocardial fibrosis in diabetic rats[J];解放軍醫學院學報;2013-06
3 MA Jie,ZHOU Zhao-feng,XU Wu,ZHANG Chao-qun,ZHANG Zhuo-qi,WANG Zhi-rong.Department of Cardiology,The Affiliated Hospital of Xuzhou Medical College,Xuzhou(221006),Jiangsu,China;Effect of Resveratrol on Enhancing Neovascularization After Myocardial Infarction in Rabbits[J];中國循環雜志;2011-02
4 LI Danyang,CHEN Peng,ZHAO Kui.Second Affliated Hospital,College of Medcine,Zhejiang University,Zhejiang Province 310009,China.;Effect of bFGF and adenosine on the angiogenesis in acute myocardial infarction model of the rabbit[J];中華急診醫學雜志;2004-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Zhang Bo;Zhang Yan-hong;Chen Li-tao;Emergency Internal Medicine Jilin Provincial People's Hospital;;Effect of Apelin-13 on myocardial remodeling in the rabbits with acute myocardial infarction[J];中國急救醫學;2019-06
2 SHANG Dong-Sheng;BIAN Yun-Fei;YANG Hui-Yu;YANG Hui-Yue;LI Xiao-Lei;Department of Cardiology,the Second Affiliated Hospital of Shanxi Medical University;;The Role of Adiponectin(APN) in Hypertension Ⅱ Infusion-induced Cardiac Inflammation and Fibrosis[J];中國動脈硬化雜志;2015-05
3 Feng Ling;Yan Xiaodong;Department of Endocrinology,Guangxi Zhuang Autonomous Region People's Hospital;;Adipokines and diabetic cardiomyopathy[J];國際內分泌代謝雜志;2015-03
4 YU Ying;ZHANG Guan-jun;ZONG Qiao-feng;WANG Xiao-mei;LI Zhen-hong;GAO Qin;Department of Physiology,Bengbu Medical College;;Mechanism investigation of low dose ethanol intervention on myocardial fibrosis in diabetic rats[J];中國臨床藥理學與治療學;2015-04
5 Ji Lu;Li Yarui;Medicine Department of Pediatrics,Shanxi Medical University;;Expression of connective tissue growth factor in the serum of children with congenital heart disease combined with pulmonary hypertension[J];中華實用兒科臨床雜志;2015-01
6 LIN Duo-Duo;ZHANG Zhi;LIU Zi-Dong;Department of Cardiology,the Third Affiliated Hospital of Liaoning Medical College;;Mechanism on Prevention and Treatment Effect of Apelin-13 for Myocardial Fibrosis in Type 2 Diabetic Rats[J];中國動脈硬化雜志;2014-10
7 SHI Tong-tong;CHENG Ming-yue;ZHANG Chao-qun;ZHANG Zhuo-qi;WANG Zhi-rong;Department of Cardiology, The Affiliated Hospital of Xuzhou Medical College;;Effect of Resveratrol on Angiogenesis of Human Umbilical Vein Endothelial Cells With the Possible Mechanisms[J];中國循環雜志;2014-08
8 SHI Tongtong;CHENG Mingyue;ZHANG Chaoqun;ZHANG Zhuoqi;WANG Zhirong;Graduate School,Xuzhou Medical College;Department of Cardiology,the Affiliated Hospital of Xuzhou Medical College;;Effects of resveratrol on the proliferation of HUVECs and expression of NO[J];徐州醫學院學報;2014-07
9 JIANG Hua;LI Qing;LI Ju-xiang;LI Gen-lin;XU Wang;YU Jian-hua;CHEN Qi;BAO Hui-hui;HU Jian-xin;HONG Kui;CHENG Xiao-shu;Department of Cardiology, The Second Affiliated Hospital of Nanchang University;;Relationship Between Plasma Homocysteine Level and Atrial Fibrillation Recurrence in Patients With Catheter Ablation[J];中國循環雜志;2014-05
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1 JIAO Hui1,ZHANG Zhi1,MA Qing-hua2,FU Wei1 1Department of Cardiology,Third Affiliated Hospital of Liaoning Medical University,Jinzhou 121001,Liaoning Province,China;2Department of Cardiology,First Affiliated Hospital of Liaoning Medical University,Jinzhou 121001,Liaoning Province,China;Effect of apelin-13 on glucose deprivation-induced autophagy of cardiomyocytes in suckling mice and its mechanism[J];解放軍醫學院學報;2013-02
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