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《Chinese Journal of Critical Care Medicine》 2019-06
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Predictive values of baseline plasma BNP levels for short-term clinical efficacy of acute heart failure patients with rhBNP treatment

Wu Zong-hu;Wang Shu-juan;Zhang Yan;Department of Cardiovascular Medicine,Zibo Central Hospital;  
Objective To explore and analyze the predictive value of baseline plasma B-type natriuretic peptide.(BNP)levels for short-term clinical efficacy of acute heart failure(AHF)patients with recombinant human brain natriuretic peptide(rhBNP)treatment.Methods From July 2015 to January 2018,192 AHF patients treated with conventional therapies and rhBNP were retrospectively analyzed in our hospital.According to the short-time clinical effect of rhBNP,the patients were divided into the effective group and ineffective group.The baseline plasma BNP levels of all patients and rhBNP diuretic effect were analyzed and compared.Results There were 21 AHF patients(10.9%)with significantly effective treatment and 97 patients(50.5%)with generally effective treatment.The total efficacy rate was 61.5%.The patients were divided into the effective group(n= 118)and ineffective group(n=74).The baseline plasma BNP levels of patients in ineffective group who had less diuretic effect was(1897.45 ±780.84)ng/L,significantly higher than that in effective group(P0.05).After 24 h treatment of rhBNP,the efficacy of patients in the ineffective group was(408.75 ±315.47)mL,lower than that in effective group(P0.05).The baseline plasma BNP levels were negatively correlated with the diuretic effect of rhBNP(r=-0.614,-0.530,-0.379,P0.05).Conclusion The baseline plasma BNP levels could be the predictions of short-term clinical efficacy of acute heart failure patients treated with rhBNP,which is worthy of clinical attention.
【CateGory Index】: R541.6
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 WU Xiaoying,ZHOU Yujie,ZHAO Yingxin,MA Hanying,LIU Xiaoli,WANG Zhijian,LI Yanfang,LI Xi De-partment of Cardiology(12th Ward),Capital Medical University affiliated Beijing Anzhen Hospital,Beijing Insti-tute of Heart,Lung and Blood Vessel Diseases,Beijing 100029,China;A clinical study of recombinant human brain natriuretic peptide on patients with acute heart failure[J];心肺血管病雜志;2011-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Wu Zong-hu;Wang Shu-juan;Zhang Yan;Department of Cardiovascular Medicine,Zibo Central Hospital;;Predictive values of baseline plasma BNP levels for short-term clinical efficacy of acute heart failure patients with rhBNP treatment[J];中國急救醫學;2019-06
2 Hu Qianpei;Xie Bo;Li Yimei;Jiang Lian;Luo Tianyong;Li Qiong;Li Yulu;Department of General Practice,Yongchuan Hospital Affiliated to Chongqing Medical University;;Effect of nesiritide on renal function of patients with heart failure:a systematic review[J];重慶醫科大學學報;2015-10
3 WANG Hui-yuan;People's Hospital of Wenshui;;Clinical effectiveness analysis of rhBNP for the treatment of patients with heart failure[J];中國實用醫刊;2015-11
4 SUI Ning;The First Internal Medicine-Cardiovascular Department,Shengjing Hospital of China Medical University;;Effect and safety of rh-BNP in the treatment of patients with heart failure[J];實用藥物與臨床;2015-05
5 LAI Xin;WANG Xi;DUAN Huinan;Department of Cardiology, Renmin Hospital of Wuhan University;;Efficacy and safety of recombinant human brain natriuretic peptidein in treatment of heart failure: a Meta-analysis[J];中國醫藥導報;2014-26
6 Liu Hongpei;Huang Tao;Department of Cardiology,the People's Hospital of Youyang County;;Curative effect of rhBNP on refractory heart failure in senile patients[J];西南國防醫藥;2014-08
7 LUO Li;HUANG Yi;Department of Cardiology,First People's Hospital of Changde City;;Observation on the Efficacy of Lyophilized Recombinant Human Brain Natriuretic Peptide for the Treatment of Patients with Acute Heart Failure[J];醫學臨床研究;2014-01
8 ZHOU Xiujin;LU Jingqian;Yuxi Teching Hospital of Dali University;First People's Hospital of Kunming;;A Clinical Study of Recombinant Human Brain Natriuretic Peptide on Patients with Acute Decompensated Heart Failure[J];大理學院學報;2013-12
9 WANG Shun-qiang;Department of Cardiology, Zichuan District Hospital,Shandong Province;;The efficacy analysis of recombinant human brain natriuretic peptide on patients with acute heart failure[J];湖南中醫藥大學學報;2013-10
10 WANG Yan-xia,HAN Ya-ling,MA Ying-yan,DONG Wei,SUN Lei,ZHANG Ping(Department of Cardiology,General hospital of Shenyang Military Region of PLA,Shenyang,Liaoning,110016,China);Observation of Clinical Efficacy of Recombinant Human Brain Natriuretic Peptide on the Treatment of Congestive Heart Failure[J];現代生物醫學進展;2013-16
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHOU Zhiming, ZHOU Yujie, XIE Ying, SHI Dongmei, LIANG Jing Department of Geriatric Cardiology, Capital University of Medical sciences Affiliated Beijing Anzhen Hospital, 100029, China;Effect of rhBNP on patients with decompensated heart failure[J];心肺血管病雜志;2008-05
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