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《Chinese Journal of Critical Care Medicine》 2019-05
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Research of clinical characteristics and prognostic factors in patients with ICU cardiac amyloidosis

Wu Mao-yuan;Xu Chuan-fen;Xu Yan;Department of Cardiology,Rizhao Municipal People's Hospital;  
Objective To retrospectively analyze the clinical characteristic and prognosis of patients with acute heart failure(AHF)entering the ICU for light-chain cardiac amyloidosis(ALCA).To evaluate the independent and related factors of death and progression to cardiogenic shock in patients with AL-CA.Methods The clinical data of patients with AL-CA who underwent AHF into the intensive care unit(ICU)of Cardiology of Rizhao Municipal People's Hospital from October 2012 to September 2018 were included.The demographic characteristics,medical history,clinical characteristics,biochemical indicators,echocardiographic parameter,treatment status and clinical prognosis of the patients were collected.The clinical characteristics of AL-CA patients and the treatment of AL-CA patients with cardiogenic shock were analyzed.The patients were divided into survival group and death group according to the death of patients within 3 months after discharge from hospital.Univariate and multivariate logistic regression analysis were used to evaluate the independent factors related to the death of patients within 3 months after discharge.The patients with cardiogenic shock who were in clinical stable state were enrolled in the cardiogenic shock group,and patients with CA who were treated at the same time and had no cardiac events within 1 year were selected as the control group by propensity score matching.Univariate and multivariate logistic regression analysis were used to evaluate independent factors associated with cardiogenic shock in patients.Of the 23 patients who received dobutamine,17 died.Results The time interval from dobutamine to patient death was(5.3 ±2.8)d.Twenty-eight(52.8%)patients were younger than 65 years old.Most patients with cardiogenic shock(86.2%,25/29)died.Multivariate analysis showed that cardiogenic shock(OR=10.329,95%CI 1.761-60.712,P0.001)and blood urea nitrogen(BUN,OR=1.256,95%CI1.088-1.561,P=0.003)were independently associated with death within 3 months of the patient.The best diagnostic cut-off value for BUN is 7.5 mmol/L.N-terminal prohormone of Btypenatriuretic peptide(NT-proBNP)(OR=8.707,95%CI 1.856-34.693,P=0.020)was independently associated with cardiogenic shock in AL-CA patients.The best diagnostic cut-off value for serum NT-proBNP is 4050 pg/mL.Conclusion AL-CA patients admitted to ICU for AHF have higher incidence and mortality of cardiogenic shock,and young patients have higher mortality.NTproBNP has a higher predictive value for evaluating prognosis.The efficacy of phentermamine is poor,and should be actively looking for better dobutamine replacement for first aid treatment.
【CateGory Index】: R541
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 Li Yingying;Zhu Wanrong;Chai Ke;Yang Jiefu;Fang Fang;He Shurong;Yang Chongqing;Wang Hua;Department of Cardiology, Beijing Hospital,National Center of Gerontology;;Myocardial amyloid deposition in patients aged over 85 years with heart failure and preserved ejection fraction[J];中華心血管病雜志;2018-06
2 Li Li;Duan Xuejing;Sun Yang;Lu Yang;Xu Hongyu;Wang Qingzhi;Wang Hongyue;Department of Pathology,Fuwai Hospital,Chinese Academy of Medical Sciences;;Classification of cardiac amyloidosis:an immunohistochemical analysis[J];中華病理學雜志;2018-02
3 Du Juan;Hou Jian;Department of Hematology,The Myeloma & Lymphoma Center, Changzheng Hospital, The Second Military Medical University;;How I treat immunoglobulin light chain amyloidosis[J];中華血液學雜志;2017-06
4 ZHANG Yan;RAO Li;Department of Cardiology,West China Hospital,Sichuan University;;Advances in Diagnosis and Treatment of Cardiac Amyloidosis[J];心血管病學進展;2015-05
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 Wang Hua;Yang Jiefu;Department of Cardiology,Beijing Hospital,National Center of Gerontology;;Prevention and management of heart failure in China:past,present and future perspective[J];中華心血管病雜志;2019-09
2 Wu Mao-yuan;Xu Chuan-fen;Xu Yan;Department of Cardiology,Rizhao Municipal People's Hospital;;Research of clinical characteristics and prognostic factors in patients with ICU cardiac amyloidosis[J];中國急救醫學;2019-05
3 Heart Failure Group of Chinese Society of Cardiology of Chinese MedicalAssociation;Chinese Heart Failure Association of Chinese Medical Doctor Association;Editorial Board of Chinese Journal of Cardiology;;Chinese guidelines for the diagnosis and treatment of heart failure 2018[J];中華心血管病雜志;2018-10
4 Ge Hongfeng;Zhou Zhenxia;Wu Mei;Chu Hailiang;Li Shue;Yang Shili;Sun Xiaoxing;Zhang Siqi;Department of Hematology,Bozhou People's Hospital;;Primary systemic amyloidosis with multiple serous cavity effusion as the outstanding manifestation:report of one case and review of literature[J];白血病·淋巴瘤;2018-06
5 Li Xiaoying;;Pay attention to the potential prevalence of cardiac amyloidosis in elderly heart failure patients with preserved ejection fraction[J];中華心血管病雜志;2018-06
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Zhang Congli;Feng Jun;Shen Kaini;Su Wei;Zhang Chunlan;Huang Xufei;Cao Xinxin;Zhang Lu;Zhou Daobin;Li Jian;Department of Hematology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences;;The diagnostic and prognostic values of serum free light chain in patients with primary light chain amyloidosis[J];中華血液學雜志;2016-11
2 Mi Tao;Zhang Cuntai;Department of Geriatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology;;Chronic heart failure in the elderly[J];中華老年醫學雜志;2016-03
3 SUN Wei-Yi;LI Jian;Department of Hematology,Peking Union Medical College Hospital;;New Advances in the Subtyping of Systemic Amyloidosis——Review[J];中國實驗血液學雜志;2014-01
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