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《Chinese Journal of Critical Care Medicine》 2019-02
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Assessment of diltiazem in heart failure with preserved left ventricular ejection fraction patients

Li Bin;Kang Ai-ling;Shen Jie;Chen De-chang;Shanghai Jiading Anting Hospital,Shanghai Jiaotong University School of Medicine;  
Objective To investigate the effectiveness of diltiazem in heart failure with preserved ejection fraction(HF-PEF) patients. Methods The study involved 87 subjects diagnosed with HF-PEF. They were randomly divided into two group: 42 subjects assigned into control group,received traditional anti-heart failure optimal medical therapy; 47 subjects assigned into treatment group, not only received traditional optimal medical therapy but also diltiazem therapy. The New York Heart Association( NYHA) functional class and six-minute walking test(6 MWT) and B-type natriuretic peptide(BNP) were recorded, ratio of mitral velocity to early diastolic velocity of the mitral annulus were detected by echocardiogram before and after treatment. The treatment lasted three months.Results The total effective rate(62. 22% vs. 47. 62%)in treatment group was higher than it in control group, while 6 MWT(m:520. 63 ±62.41 vs. 223.64 ±23.47) and E/E'(8.28 ±4.92 vs. 10.28 ±5.21) and BNP(pg/mL: 223. 64 ±23. 47 vs. 170. 36 ±21. 39) in treatment group after treatment improved significantly than those in control group. There was statistically significant difference(P 0. 05). Conclusion Diltiazem could improve the symptoms and cardiac diastolic function in HF-PEF.
【Fund】: 上海市衛生和計劃生育委員會科研課題(20134375)
【CateGory Index】: R541.6
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Muhammad Asrar ul Haq;Chiew Wong;Vivek Mutha;Nagesh Anavekar;Kwang Lim;Peter Barlis;David L Hare;Department of Cardiology,The Northern Hospital;Department of Medicine,University of Melbourne;Department of Cardiology,The Northern Hospital,Epping;;Therapeutic interventions for heart failure with preserved ejection fraction:A summary of current evidence[J];World Journal of Cardiology;2014-02
2 YE Bing-hua,LI Ai-yun, ZHU Xiao-yanDepartment of Cardiology,Taizhou Municipal Gaogang District People's Hospital.Taizhou 225321,China;Carvedilol on the management of diastolic heart failure[J];中國心血管病研究雜志;2005-11
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 Li Bin;Kang Ai-ling;Shen Jie;Chen De-chang;Shanghai Jiading Anting Hospital,Shanghai Jiaotong University School of Medicine;;Assessment of diltiazem in heart failure with preserved left ventricular ejection fraction patients[J];中國急救醫學;2019-02
2 Zhao Guoyuan;Zhao Zhiqiang;Mao Jingyuan;Wang Xianliang;Wang Shuai;Tianjin University of Traditional Chinese Medicine;First Teaching Hospital,Tianjin University of Traditional Chinese Medicine;;Current Situation of Clinical Research of Heart Failure with Normal Ejection Fraction[J];中西醫結合心腦血管病雜志;2015-16
3 MA Cai-yan;TO Hong;XIE Pei-yi;LI Xiao-ling;YE Jian-hua;Department of Cardiology,Tongde Hosipital of Zhejiang Province;;Clinical study of Wenyangfang in the treatment of heart failure[J];中國臨床藥理學雜志;2015-01
4 CHU Song-yun;PENG Fen;ZHAO Jing;Department of Cardiology,Peking University First hospital;;Clinical study of different risk factors on prognosis among chronic heart failure patients of different genders[J];中華老年心腦血管病雜志;2014-10
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